Improving the Yield and Quality of Daptomycin in Streptomyces roseosporus by Multilevel Metabolic Engineering
Daptomycin is a cyclic lipopeptide antibiotic with a significant antibacterial action against Thermal Fuse antibiotic-resistant Gram-positive bacteria.Despite numerous attempts to enhance daptomycin yield throughout the years, the production remains unsatisfactory.This study reports the application of multilevel metabolic engineering strategies in