Adipocyte Xbp1s overexpression drives uridine production and reduces obesity

Adipocyte Xbp1s overexpression drives uridine production and reduces obesity

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Objective: The spliced transcription factor Xbp1 (Xbp1s), a transducer of the unfolded protein response (UPR), regulates lipolysis.Lipolysis is stimulated by fasting when uridine synthesis is also activated in adipocytes.Methods: Here Heat Therapy Pack we have examined the regulatory role Xbp1s in stimulation of uridine biosynthesis in adipocytes and triglyceride mobilization using inducible mouse models.Results: Xbp1s is a key molecule involved in adipocyte uridine biosynthesis and release by activation of carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, dihydroorotase (CAD), the rate-limiting enzyme for UMP biosynthesis.Adipocyte Xbp1s overexpression drives energy mobilization and protects mice from obesity through activation of the pyrimidine biosynthesis pathway.

Conclusion: These observations reveal that Xbp1s is a potent stimulator of uridine production Girls Fall Casual Set in adipocytes, enhancing lipolysis and invoking a potential anti-obesity strategy through the induction of a futile biosynthetic cycle.Keywords: Obesity, Xbp1, ER stress, UPR, Pyrimidine, Uridine, CAD.